Caprion

Accelerating precision medicine™

Allergy

Background

An allergy is defined as a hypersensitivity of the immune system to allergens in the environment. Allergen-specific immunoglobulin, or IgE, is produced upon recognition of the allergen. This leads to excessive activation of mast cells and basophils resulting in an inflammatory response.

Allergy Expertise

ImmuneCarta has expertise in assay development that supports the advancement of novel therapeutics for allergy and atopy, including:

  • IgE-dependent degranulation of basophils utilization the BAT (Basophil Activation Test) assay
  • Phenotypic and functional analysis of specific cell subsets
  • ICS (Intracellular Cytokine Staining) on whole blood for IL-1, IL-6, and IL-8 production by innate cells (monocytes, eosinophils, neutrophils)
  • T, B, and NK cell subset enumeration in whole blood
  • Measurement of blood immunoglobulins, including IgE and IgG isotypes
  • Quantification of eosinophils and neutrophils in Bronchoalveolar Lavage Fluid (BALF) by flow cytometry
  • Measurement of mediators (cytokines, chemokines, leukotrienes) in BALF, sputum, or other fluids


CD63 expression on activated and inactivated basophils (HLA-DR-CD123+)