ImmuneCarta

Accelerating precision medicine™

Infectious Diseases

Background

The immune system constitutes the body’s defense against pathogenic microorganisms (bacteria, virus, parasites, and fungi). The innate immune system provides early defense and induces an adaptive response to clear the foreign invaders and establish long-term immunological memory.

One of the greatest successes in public health is the reduction in the prevalence and incidence of infectious diseases through the use of vaccines. Vaccines “simulate” a natural infection in order to “prime” the immune system so that exposure to the antigen results in a fast and efficient immune response.

Expertise in Infectious Diseases

ImmuneCarta has extensive experience studying the immune response to viruses, including Influenza, HIV, HCV, CMV and EBV.

immune response monitoring for vaccines against HIV and other infection diseases

ImmuneCarta has experience in HIV viral latency studies and develops customized assays to determine whether latently infected cells can be reactivated in vitro.

 

We have the expertise and tools to interrogate the host’s innate and adaptive arms of the immune system. Our services include:

  • Customization of flow cytometry panels designed to detect pathogen-specific responses
  • Monitoring of mounted immune responses to licensed and exploratory vaccines to H5N1 influenza, HIV and others
  • Preparation of monocyte-derived dendritic cells (MDDC) for co-culture experiments
  • Immune monitoring experiments to evaluate the proliferative responses, cytokine secretion and memory subset distribution of CD4+ and CD8+ T cells in HIV-infected individuals vaccinated with autologous dendritic cells loaded with HIV antigens